Cold sores are small, painful, fluid-filled blisters or sores that appear on the lips, mouth, or nose that are caused by a virus. The sores can be painful and usually last a few days. Unlike most viral infections, the cold sore virus is not completely eliminated by the body defenses. For this reason, cold sores often recur.
After the first infection, the virus enters the nerve cells and travels up the nerve until it comes to a place called a ganglion, which is a collection of nerve cells. There, it resides quietly in a stage that is called a "dormant" or "latent" period. At times, the virus can start multiplying again and travel down the nerve to the skin, causing new cold sores. The exact way this happens is not clear, but it is known that some conditions seem to be associated with recurrences, including
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